Drugs that dissolve in the gut  Drugs that dissolve in the gut  Drugs that dissolve in the gut

Here is a video showing an experiment to understand the mechanism of drugs. Let's write a report on the expected results of the experiment and what you learned from watching the video.

 Why doesn't it dissolve in the stomach?
Why doesn't it dissolve in the stomach?

Some drugs are not dissolved in the stomach, but are dissolved after entering the intestines. It seems that gastric juice digests food and medicines, but how are these medicines kept from dissolving in the stomach? Such medicines are made to pass through the stomach by taking advantage of the difference in acidity between the stomach and the intestines.

 Experiment  Experiment
Click the play button on the video to see how it actually works!
Drugs are used to cure diseases and injuries. If not used correctly, they can be harmful to the body, so don't imitate the experiments.
 Results of the experiment!
Results of the experiment!

The drug does not dissolve in acidic liquid, which is the same as gastric juice, but it dissolves in neutral liquid, which is the same as intestinal juice.

Tablets that dissolve in the intestines have a coating that prevents them from dissolving when they are highly acidic. As the acidity weakens and the drug becomes more neutral or alkaline, the coating breaks off and the drug begins to dissolve. In cases where dissolving in the stomach would cause a problem, this is done so that the drug will dissolve after it is safely transported to the intestines. To take advantage of the ingenuity of the tablets, do not chew them, but take them as they are.

 The drug does not dissolve in acidic liquid, which is the same as gastric juice, but it dissolves in neutral liquid, which is the same as intestinal juice.  The drug does not dissolve in acidic liquid, which is the same as gastric juice, but it dissolves in neutral liquid, which is the same as intestinal juice.
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Supervised by Mayumi Mochizuki (Professor Emeritus, Keio University)